![]() Over 27% of the different-strand-overlap relationships are shared between human and mouse, compared to only ~8% conservation for same-strand-overlap relationships. The length difference between the two different-strand overlapping genes is less dramatic. Most of the same-strand overlapping gene pairs show at least a tenfold difference in length, much larger than the length difference between non-overlapping neighboring gene pairs. The majority of the same-strand overlaps are embedded forms, whereas most different-strand overlaps are not embedded and in the convergent transcription orientation. ![]() ResultsĪbout 10% of the genes under study are overlapping genes, the majority of which are different-strand overlaps. ![]() ![]() In this study we identified and characterized the overlapping genes in a set of 13,484 pairs of human-mouse orthologous genes. Increasing evidence suggests that overlapping genes are much more common in eukaryotic genomes than previously thought. ![]()
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